نمایش پرونده ساده آیتم

dc.contributor.authorCharkhpour, M
dc.contributor.authorSamadi, H
dc.contributor.authorBahari, B
dc.contributor.authorParvizpur, A
dc.date.accessioned2018-08-26T08:54:54Z
dc.date.available2018-08-26T08:54:54Z
dc.date.issued2011
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/54217
dc.description.abstractObjectives: There are different and sometimes paradoxical reports about the effects of adenosine agonists and antagonists (specially in i.p. administration) in withdrawal syndrome of morphine. In the present study, the effects of N 6-cyclopentyladenosine (CPA, A1 receptor agonist) in morphine withdrawal syndrome were investigated on NMRI rats (200- 240 g). Methods: Dependency was induced by i.p. injection of increasing doses of morphine for nine days. One hour after the last dose of morphine, withdrawal syndrome (jumping, standing on feet, abdomen writhing, wet-dog shake, genital grooming and teeth chattering) was induced by i.p. administration of naloxone. To investigate the effects of A1 receptor agonist in morphine withdrawal syndrome, CPA (20, 40, 80, ?g/5?l/rat) was administered by i.c.v. route. Data were analyzed with one way anova and independent t test. Results: CPA decreased naloxone-induced jumping-standing on feet and abdomen writhing (P<0.001) in all doses, however wetdog shake (P<0.05), teeth chattering (P<0.001) and genital grooming (P<0.01) were decreased by CPA in 40 and 80 ?g/rat. Conclusion: The results indicate that CPA can decrease all naloxone-induced withdrawal symptoms and the effects on jumping-standing on feet, teeth chattering and genital grooming were dose-dependent.
dc.language.isoArabic
dc.relation.ispartofPharmaceutical Sciences
dc.subject6 n cyclopentyladenosine
dc.subjectadenosine A1 receptor
dc.subjectmorphine
dc.subjectnaloxone
dc.subjectanalysis of variance
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdata analysis
dc.subjectdose response
dc.subjectdrug effect
dc.subjectjumping
dc.subjectmorphine addiction
dc.subjectmorphine withdrawal syndrome
dc.subjectnonhuman
dc.subjectoutcome assessment
dc.subjectrat
dc.subjectStudent t test
dc.subjectwet dog shakes
dc.subjectwithdrawal syndrome
dc.titleEvaluation the effect of intracerebroventricular injection of CPA (N 6-cyclopentyladenosine) on withdrawal syndrome of morphine in rats
dc.typeArticle
dc.citation.volume17
dc.citation.issue3
dc.citation.spage163
dc.citation.epage172
dc.citation.indexScopus


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