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dc.contributor.authorCharkhpour, M
dc.contributor.authorDelazar, A
dc.contributor.authorMohammadi, H
dc.contributor.authorGholikhani, T
dc.contributor.authorParvizpur, A
dc.date.accessioned2018-08-26T08:54:46Z
dc.date.available2018-08-26T08:54:46Z
dc.date.issued2014
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/54196
dc.description.abstractBackground: Opioidal analgesics are one of the most important drugs that have been widely used in attenuating moderate to severe pain. Unfortunately, the problems of long term use of opiods are tolerance, dependence, and ultimately addiction to mentioned drugs. Glial cells (microglia and astrocyte) and pro-inflammatory cytokines are important factors in morphine tolerance and withdrawal symptoms. It has been demonstrated that Artemisia austriaca extract has antinociceptive and anti-inflammatory properties. In this study the effect of total methanolic extract of aerial parts of Artemisia austrica on withdrawal syndrome of morphine in male rats has been evaluated. Methods: Adult male Wistar rats were rendered morphine-dependent by injection of additive doses of morphine subcutaneously twice daily for 9 days. To determine the effect of Artemisia austriaca extract on morphine withdrawal syndrome, 12 hours after the last injection of morphine, different doses of the methanolic extract of Artemisia austriaca (100, 200, 400 mg/kg, i.p.) dissolved in (%25DMSO in saline), was injected and after 30 minutes, naloxone (4 mg/kg, i.p.) was injected and withdrawal signs were recorded for 45 minutes. Results: The results showed that methanolic extract of Artemisia austriaca could reduce the morphine withdrawal symptoms in a dose-dependent manner. Conclution: The results of the present study indicate that Artemisia austriaca has beneficial effects in reducing withdrawal syndrome of morphine. The underlying mechanisms of this effect may consist of reduction of inflammatory response and attenuating of pro-inflammatory cytokines activation by its alkaloids content.
dc.language.isoEnglish
dc.relation.ispartofPharmaceutical Sciences
dc.subjectartemisia austriaca methanolic extract
dc.subjectdrugs used in the treatment of addiction
dc.subjectmorphine
dc.subjectnaloxone
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectadult
dc.subjectanimal behavior
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArtemisia
dc.subjectArtemisia austriaca
dc.subjectarticle
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectdose time effect relation
dc.subjectdrug dependence treatment
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectdrug megadose
dc.subjectmale
dc.subjectmonotherapy
dc.subjectmorphine addiction
dc.subjectmorphine withdrawal syndrome
dc.subjectnonhuman
dc.subjectrat
dc.subjecttreatment response
dc.subjectwithdrawal syndrome
dc.titleEvaluation of the effects of artemisia austriaca on morphine withdrawal syndrome in rats
dc.typeArticle
dc.citation.volume20
dc.citation.issue1
dc.citation.spage1
dc.citation.epage5
dc.citation.indexScopus


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