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dc.contributor.authorGoldust, M
dc.contributor.authorTalebi, M
dc.contributor.authorMajidi, J
dc.contributor.authorSaatlou, MAR
dc.contributor.authorRezaee, E
dc.date.accessioned2018-08-26T08:54:21Z
dc.date.available2018-08-26T08:54:21Z
dc.date.issued2013
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/54122
dc.description.abstractObjective: Cerebral stroke in young adults is not uncommon. Venous thromboses resulting from antiphospholipid antibodies (APAs) are one of causes of stroke in youths. This study aimed at evaluating the role of APAs in young patients with ischemic strokes. Methods: In this case-control study, 25 patients with diagnosis of ischemic stroke or transient ischemia attack in case group and 40 patients in control group were studied during one year. Medical history was obtained from all the patients. Levels of anticardiolipin and antiphospholipid antibodies including both IgG and IgM, were evaluated in all patients before consuming warfarin and using ELISA method. Results: Antiphospholipid antibodies or anticardiolipin antibody was high in six (24%) patients. In the control group, only two subjects had abnormally increased amounts of at least one antibody. The difference was significant between the case and control groups (P < .05). The study demonstrated that history of at least one cerebral ischemic event was observed in two out of 6 patients (33.3%) with high APAs and two out of 19 patients (10.5%) without higher APAs. Conclusion: APAs increase risk of ischemic strokes independently or in association with other vascular risk factors. é 2013 Informa Healthcare USA, Inc.
dc.language.isoEnglish
dc.relation.ispartofInternational Journal of Neuroscience
dc.subjectcardiolipin antibody
dc.subjectimmunoglobulin G
dc.subjectimmunoglobulin M
dc.subjectphospholipid antibody
dc.subjectwarfarin
dc.subjectadolescent
dc.subjectadult
dc.subjectantibody blood level
dc.subjectarticle
dc.subjectbrain ischemia
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical history
dc.subjecttransient ischemic attack
dc.titleEvaluation of antiphospholipid antibodies in youths suffering from cerebral ischemia
dc.typeArticle
dc.citation.volume123
dc.citation.issue3
dc.citation.spage209
dc.citation.epage212
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.3109/00207454.2012.749256


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