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dc.contributor.authorRafieian-Kopaei, M
dc.contributor.authorNasri, H
dc.contributor.authorNematbakhsh, M
dc.contributor.authorBaradaran, A
dc.contributor.authorGheissari, A
dc.contributor.authorRouhi, H
dc.contributor.authorAhmadi Soleimani, SM
dc.contributor.authorBaradaran-Ghahfarokhi, M
dc.contributor.authorGhaed-Amini, F
dc.contributor.authorArdalan, M
dc.date.accessioned2018-08-26T08:54:03Z
dc.date.available2018-08-26T08:54:03Z
dc.date.issued2012
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/54069
dc.description.abstractBackground: Investigations have attempted to modify the outcome of tubular injury by either ameliorating renal tubular damage or promoting tubular regeneration in the case of acute tubular necrosis. Objectives: We investigated the protective effect of Eprex an erythropoietin analogue on tubular injury induced by gentamicin (GM). Materials and Methods: Forty male Wistar rats were randomly divided into four groups. In group 1,rats were served as a sham group. In group 2, rats were injected intraperitoneally with 100 mg/kg of GM for 10 consecutive days (positive control group) and then were sacrificed. In group 3, rats received GM for 10 days then Eprex 100U/kg was injected intraperitoneally for the next 10 days and then they were sacrificed at the day 20th. In group 4 rats were injected a combination of GM (80 mg/kg) and Eprex 100U/kg intraperitoneally for 10 days and then were sacrificed. Results: The results indicated that, Eprex prevented the increase in serum creatinine (Cr) and blood urea nitrogen (BUN). The effect of Eprex on damage score, showed that co-administration of GM and Eprex (group 3 and 4) reduced the kidney tissue damage compared to positive control group (P<0.05). This result indicat that Eprex potentially can reduce or prevent the kidney tissue damage. Conclusions: Ameliorative effect of Eprex when the drug was given in combination with GM and also when the drug was applied after GM-induced tubular damage, revealed the renoprotective potency of Eprex. Eprex is a promising drug to prevent or attenuate tubular damage induced by GM or other nephrotoxic agents which act through the same mechanisms as gentamicin. é 2012, Society of Diabetic Nephropathy Prevention. All rights reserved.
dc.language.isoEnglish
dc.relation.ispartofJournal of Nephropathology
dc.titleErythropoietin ameliorates genetamicin-induced renal toxicity: A biochemical and histopathological study
dc.typeArticle
dc.citation.volume1
dc.citation.issue2
dc.citation.spage109
dc.citation.epage116
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.5812/nephropathol.7533


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