نمایش پرونده ساده آیتم

dc.contributor.authorAboomardani, M
dc.contributor.authorRafraf, M
dc.contributor.authorArefhosseini, R
dc.contributor.authorRashidi, MR
dc.date.accessioned2018-08-26T08:52:52Z
dc.date.available2018-08-26T08:52:52Z
dc.date.issued2012
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/53827
dc.description.abstractObjectives: Thalassemic patients are seriously at risk of serum dislipidemia, zinc deficiency and tissue damage due to oxidative stress induced by iron storage. In biologic systems, zinc may interact with iron and inhibit oxidative and reductive reactions resulted by iron and other chimiooxidative agents. The aim of this study was to evaluate the effect of zinc supplementation on serum Malondealdehyde (MDA) and lipid profiles in beta thalassemia major patients. Methods: In this clinical trial, 60 beta thalassemia major patients (male & female) older than 18 years old were assigned randomly in two groups as intervention and control groups(30 per group). The intervention group ingested zinc supplement as 220 mg zinc sulfate capsule contented 50 mg elemental zinc daily for 3 months. The control group did not receive any supplement in that time. Information about general characteristics, weight, height and dietary intake were gathered before and after the end of study. Blood samples were obtained from each subject prior and after the study and serum zinc, MDA, triglyceride, LDL-C and HDL-C levels were measured. Data analyzed with paired t-test, independent t-test and ANOVA. Results: Zinc supplementation caused significant increasing in daily caloric intake, body mass index, serum zinc and HDL-C levels and significant reduction in LDL-C levels in intervention group. No significant variations were observed for other variables in both of groups. Conclusion: Zinc supplementation had beneficial effects on serum lipid profiles in studied beta thalassemic patients and might have suitable role in delaying cardiovascular disease risks in these patients.
dc.language.isoArabic
dc.relation.ispartofPharmaceutical Sciences
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlow density lipoprotein cholesterol
dc.subjectmalonaldehyde
dc.subjecttriacylglycerol
dc.subjectzinc
dc.subjectzinc sulfate
dc.subjectadult
dc.subjectanalysis of variance
dc.subjectarticle
dc.subjectblood sampling
dc.subjectbody height
dc.subjectbody mass
dc.subjectbody weight
dc.subjectcaloric intake
dc.subjectcardiovascular risk
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectdiet supplementation
dc.subjectdietary intake
dc.subjectdrug capsule
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectrandomized controlled trial
dc.subjectStudent t test
dc.subjectthalassemia major
dc.subjecttriacylglycerol blood level
dc.subjectzinc blood level
dc.titleEffect of zinc supplementation on serum mlondealdehyde and lipid profiles on beta thalassemia major patients
dc.typeArticle
dc.citation.volume18
dc.citation.issue1
dc.citation.spage25
dc.citation.epage32
dc.citation.indexScopus


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