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dc.contributor.authorJelvehgari, M
dc.contributor.authorMaghsoodi, M
dc.contributor.authorNemati, H
dc.date.accessioned2018-08-26T08:51:42Z
dc.date.available2018-08-26T08:51:42Z
dc.date.issued2010
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/53494
dc.description.abstractThe objective of the present investigation was to design a sustained release floating microcapsules of theophylline using two polymers of different permeability characteristics; Eudragit RL 100 (Eu RL) and cellulose acetate butyrate (CAB) using the oil-in-oil emulsion solvent evaporation method. Polymers were used separately and in combination to prepare different microcapsules. The effect of drug-polymer interaction was studied for each of the polymers and for their combination. Encapsulation efficiency, the yield, particle size, floating capability, morphology of microspheres, powder X-ray diffraction analysis (XRD), and differential scanning calorimetry (DSC) were evaluated. The in vitro release studies were performed in PH 1.2 and 7.4. The optimized drug to polymer ratios was found to be 4:1 (F2) and 0.75:1 (F2) with Eu RL and CAB, respectively. The best drug to polymer ratio in mix formulation was 4:1:1 (theophylline: Eu RL: CAB ratio). Production yield, loading efficiencies, and particle size of F2 and F 2 were found to be 59.14% and 45.39%, 73.93% and 95.87%, 372 and 273 micron, respectively. Microsphere prepared with CAB showed the best floating ability (80.3 آ± 4.02% buoyancy) in 0.1 M HCl for over 12 h. The XRD and DSC showed that theophylline in the drug loaded microspheres was stable and in crystaline form. Microparticles prepared using blend of Eu RL and CAB polymers indicated more sustained pattern than the commercial tablet (P<0.05). Drug loaded floating microballoons prepared of combination of Eu RL and CAB with 1:1 ratio were found to be a suitable delivery system for sustained release delivery of theophylline which contained lower amount of polymer contents in the microspheres.
dc.language.isoEnglish
dc.relation.ispartofResearch in Pharmaceutical Sciences
dc.subjectcellaburate
dc.subjectcrystallin
dc.subjecteudragit
dc.subjectfloating microballoon
dc.subjectmicrosphere
dc.subjectsolvent
dc.subjecttheophylline
dc.subjectunclassified drug
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdifferential scanning calorimetry
dc.subjectdrug delivery system
dc.subjectdrug formulation
dc.subjectdrug penetration
dc.subjectemulsion
dc.subjectencapsulation
dc.subjectevaporation
dc.subjectin vitro study
dc.subjectmicrocapsule
dc.subjectparticle size
dc.subjectpH
dc.subjectsustained drug release
dc.subjecttablet
dc.subjectX ray powder diffraction
dc.titleDevelopment of theophylline floating microballoons using cellulose acetate butyrate and/or Eudragit RL 100 polymers with different permeability characteristics
dc.typeArticle
dc.citation.volume5
dc.citation.issue1
dc.citation.spage33
dc.citation.epage43
dc.citation.indexScopus


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