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dc.contributor.authorReisi, P
dc.contributor.authorAlaei, H
dc.contributor.authorBabri, S
dc.contributor.authorSharifi, MR
dc.contributor.authorMohaddes, G
dc.contributor.authorSoleimannejad, E
dc.date.accessioned2018-08-26T08:51:36Z
dc.date.available2018-08-26T08:51:36Z
dc.date.issued2009
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/53459
dc.description.abstractPrevious studies have indicated an association between diabetes mellitus and impairments in synaptic plasticity in the hippocampus. However, it is not clear if the impairments of synapses are pre- or post-synaptic or both. The aim of this study was to evaluate the extracellular basal levels of glutamate and GABA at dentate gyrus of anesthetized streptozotocin-induced diabetic rats, after 12 weeks of diabetes induction. Extracellular levels of glutamate and GABA were investigated by using the microdialysis technique coupled to high performance liquid chromatography (HPLC) with fluorescent detection. Experimental groups were the control group and the diabetes group. The results showed that glutamate levels were significantly decreased in diabetes group compared to the control group, while GABA levels showed no changes. The findings support the possibility that alterations in transmission may account, in part, for synaptic plasticity deficits induced in diabetes. é 2009 Elsevier Ireland Ltd. All rights reserved.
dc.language.isoEnglish
dc.relation.ispartofPathophysiology
dc.subject4 aminobutyric acid
dc.subjectglutamic acid
dc.subjectstreptozocin
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectdentate gyrus
dc.subjectfluorescence
dc.subjecthigh performance liquid chromatography
dc.subjectmale
dc.subjectmicrodialysis
dc.subjectnerve cell plasticity
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectstreptozocin diabetes
dc.titleDetermination of the extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats
dc.typeArticle
dc.citation.volume16
dc.citation.issue1
dc.citation.spage63
dc.citation.epage66
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1016/j.pathophys.2009.03.003


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