Deferiprone solubility in some non-aqueous mono-solvents at different temperatures: experimental data and thermodynamic modelling

Abstract

The solubility of deferiprone (DFP) in five organic solvents including ethyl acetate, chloroform, acetonitrile, 1,4-dioxane and dichloromethane was investigated by the flask-shake method under atmospheric pressure at temperatures ranging from 293.15 to 313.15آ K. In general, the solubility (mol L-1) obeyed the following order from high to low in different mono-solvents: dichloromethane > chloroform > acetonitrile > 1,4-dioxane > ethyl acetate. The solubility of DFP in the mono-solvents increased with a rise of temperature. The solubility data were successfully correlated with the van't Hoff equation. The generated data in this work and the previously published data were used to calculate the thermodynamic parameters of the system using the modified van't Hoff equation, and the derived thermodynamic properties were correlated using Abraham solvation parameters. é 2017, é 2017 Informa UK Limited, trading as Taylor & Francis Group.