Comparison of left ventricular function between patients with non-alcoholic fatty liver disease and healthy individuals

Abstract

Non-alcoholic fatty liver disease, as an independent risk factor for development of cardiovascular events plays an increasingly prominent role worldwide.In this study, we evaluated systolic and diastolic functional parameters of left ventricles in NAFLD patients.30 normotensive, non-diabetic, non-obese NAFLD patients and 30 controls underwent laboratory examinations, liver ultrasound and finally a complete echocardiographic study including conventional, 4D and speckle tracking echocardiography. NAFLD patients had increased LAVI (30.47آ± 7.71 vs 25.1آ± 4.03, p=0.001) and DT (192.47آ±1 42.4 vs 163.13آ± 17.1, p=0.001) compared to the controls. E/A ratio was 1.12آ±0.24 in NAFLD patients and 1.27آ±0.18 in healthy individuals, p=0.01. LVEF% was 54.81آ±6.72 on 2DE and 55.83آ±8.03 on 4DE among patient group; and also 57.43آ±7.3 on 2DE, and 59.75آ±7.4 on 4DE among control group (p=0.79 and 0.59 respectively).GPSS was significantly lower in patient group in comparison with healthy individuals (18.96آ±2.31 vs 20.27آ±1.72, p=0.016), using speckle tracking technique.NAFLD patients have systolic and diastolic LV dysfunction even in the absence of hypertension, obesity and diabetes.