| dc.description.abstract | Introduction: Heat injury, with creation of conclusive necrosis in skin layers, prepares an environment suitable for bacterial infection as a result of low tissue perfusion and high protein content. Gram negative bacteries especially Pseudomonas Auroginosa have been recognized as the main creative organisms of wound infection mortality. Mankind has been interested in remedial role of honey since long. Materials and Methods: Sixty Indian piggies were categorized in three equal groups. Apart of their body, approximately 8.5cm 2, was burned with water steam (3 degree of burn). Then, a number of 108 microorganisms of Pseudomonas Auroginosa were inoculated in the wound area. Each group was treated with group-specialized drug for a period of one month. (Honey- silver sulfadiazine 1%-acetat mafenid 8.5%). In special days, according to determined schedule, animals' weight, as well as burn condition and extent were recorded and quantitative and qualitative cultural specimens were prepared periodically. The results were analyzed by statistical software of SPSS10. Results: Out of three groups, the group of honey had the mortality at least equal with two other groups(30% with comparison of 40% and 45%), the most formation of granulation tissue in a time of 10 days (90% with comparison of 35% and 44%), the smallest remaining wound at the end of study(percent of dwindle in size 62% in honey group with comparison of 29% and 22%) and the least of contamination in prepared specimens(20% in 10th day of burn with comparison of 95% and 100%). Conclusion: Utilization of topical honey in treatment of deep and infectious burn in piggies not only accelerates the healing procedure but has antimicrobial effect at least equal to valuable acetate mafenid drug. | |
