نمایش پرونده ساده آیتم

dc.contributor.authorSayyah-Melli, M
dc.contributor.authorMobasseri, M
dc.contributor.authorGharabaghi, PM
dc.contributor.authorOuladsahebmadarek, E
dc.contributor.authorRahmani, V
dc.date.accessioned2018-08-26T08:40:15Z
dc.date.available2018-08-26T08:40:15Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/53098
dc.description.abstractObjective To evaluate the effect of letrozole in combination with cabergoline and letrozole alone on regression of symptomatic uterine myomas in women of reproductive age. Design Randomized controlled clinical trial. Setting University hospital. Patients Ninety-one women of reproductive age were enrolled in the study and 88 women were eligible. Eight participants were excluded from the study. Interventions Eighty women of reproductive age with symptomatic myomas >4آ cm were evaluated in two groups. Participants in Group 1 received 2.5آ mg letrozole once daily and cabergoline 0.5آ mg/week from the first day of the menstrual cycle for 12 weeks, and participants in Group 2 received letrozole alone. Main outcome measures Changes in uterine size and volume; myoma size, volume and number; and side effects of treatment. Results Overall, 76 patients completed the study. Compared with baseline values, mean uterine volume was reduced significantly in both groups (pآ =آ 0.01), and there was no significant difference between groups (pآ =آ 0.99). The mean number of dominant myomas was reduced significantly in both groups (pآ =آ 0.03), with no significant difference between groups (pآ =آ 0.6). The mean volume of myomas was reduced significantly in both groups (pآ =آ 0.01), with no significant difference between groups (pآ =آ 0.45). Although a significant decrease in number and volume of myomas was documented in each group (pآ <آ 0.05), the intergroup analyses did not reveal significant differences between the two groups in terms of the change in number (pآ =آ 0.28) and volume (pآ =آ 0.96) of myomas. Headache was significantly more common in the letrozoleآ +آ cabergoline group (nine vs two cases, pآ =آ 0.02), but the two groups were comparable for the remaining minor side effects. Conclusion This study showed that 12 weeks of treatment with letrozole with and without cabergoline improved the size and volume of the uterus and myomas, led to symptom improvement, and could be used for short-term treatment prior to surgery or fertility programmes. Condensation Condensation letrozole in combination with cabergoline in the management of uterine fibroids. é 2016 Elsevier Ireland Ltd
dc.language.isoEnglish
dc.relation.ispartofEuropean Journal of Obstetrics Gynecology and Reproductive Biology
dc.subjectcabergoline
dc.subjectletrozole
dc.subjectantineoplastic agent
dc.subjectaromatase inhibitor
dc.subjectcabergoline
dc.subjectergoline derivative
dc.subjectletrozole
dc.subjectnitrile
dc.subjecttriazole derivative
dc.subjectadult
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectflushing
dc.subjectheadache
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmusculoskeletal pain
dc.subjectorgan size
dc.subjectpatient satisfaction
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectside effect
dc.subjectuniversity hospital
dc.subjectuterus myoma
dc.subjectvomiting
dc.subjectcombination drug therapy
dc.subjectcomparative study
dc.subjectdrug effects
dc.subjectleiomyoma
dc.subjectmiddle aged
dc.subjectuterus
dc.subjectuterus cancer
dc.subjectAdult
dc.subjectAntineoplastic Agents
dc.subjectAromatase Inhibitors
dc.subjectDrug Therapy, Combination
dc.subjectErgolines
dc.subjectFemale
dc.subjectHumans
dc.subjectLeiomyoma
dc.subjectMiddle Aged
dc.subjectNitriles
dc.subjectTriazoles
dc.subjectUterine Neoplasms
dc.subjectUterus
dc.titleComparing the effect of aromatase inhibitor (letrozole) + cabergoline (Dostinex) and letrozole alone on uterine myoma regression,a randomized clinical trial
dc.typeArticle
dc.citation.volume210
dc.citation.spage257
dc.citation.epage264
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1016/j.ejogrb.2016.11.001


فایلهای درون آیتم

فایلهاسایزفرمتنمایش

هیچ فایل مرتبطی وجود ندارد

این آیتم در مجموعه های زیر مشاهده می شود

نمایش پرونده ساده آیتم