Combination of Vortex-Assisted Liquid-Liquid Extraction and Air-Assisted Liquid-Liquid Microextraction for the Extraction of Bisphenol A and Bisphenol B in Canned Doogh Samples

Abstract

A sensitive, rapid, and efficient analytical method based on vortex-assisted liquid-liquid extraction combined with air-assisted liquid-liquid microextraction using high performance liquid chromatography-variable wavelength detection has been developed for the extraction and determination of bisphenol A and bisphenol B in canned doogh samples. In this method, the analytes are partitioned into n-hexane during liquid-liquid extraction and then they are enriched using the following air-assisted liquid-liquid microextraction procedure in a few microliters of an ammonia solution used as an extraction solvent. Under the optimum conditions, limits of detection and quantification were 0.82 and 0.54 and 2.7 and 1.5 ng mL?1, for bisphenol A and bisphenol B, respectively. The extraction recoveries and enrichment factors of the selected analytes were 86 and 81% and 4300 and 4050, respectively. The relative standard deviations were lower than 9% for intra- (n = 6) and inter-day (n = 4) precisions at a concentration of 5 ng mL?1 of each analyte. Finally, some canned doogh samples were effectively analyzed by the proposed method. é 2018 Springer Science+Business Media, LLC, part of Springer Nature