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dc.contributor.authorDanafar, H
dc.contributor.authorRostamizadeh, K
dc.contributor.authorDavaran, S
dc.contributor.authorHamidi, M
dc.date.accessioned2018-08-26T08:39:21Z
dc.date.available2018-08-26T08:39:21Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/53018
dc.description.abstractCo-delivery strategy has been proposed to minimize the amount of each drug and to achieve the synergistic effect for cancer therapies. A conjugate of the antitumor drug, doxorubicin, with diblock methoxy poly (ethylene glycol)-poly caprolactone (mPEG-PCL) copolymer was synthesized by the reaction of mPEG-PCL copolymer with doxorubicin in the presence of p-nitrophenylchloroformate. The conjugated copolymer was characterized in vitro by 1H-NMR, FTIR, DSC and GPC techniques. Then, the doxorubicin conjugated mPEG-PCL(DOX-mPEG-PCL) was self-assembled into micelles in the presence of curcumin in aqueous solution. The resulting micelles were characterized further by various techniques such as dynamic light scattering (DLS) and atomic force microscopy (AFM).The encapsulation efficiency of doxorubicin and curcumin were 82.31 آ± 3.32 and 78.15 آ± 3.14%, respectively. The results revealed that the micelles formed by the DOX-mPEG-PCL with and without curcumin have spherical structure with average size of 116 and 134 nm respectively. The release behavior of curcumin and doxorubicin loaded to micelles were investigated in a different media. The release rate of micelles consisted of the conjugated copolymer was pH dependent as it was higher at lower pH than in neutral condition. Another feature of the conjugated micelles was a sustained release profile. The cytotoxicity of micelles were evaluated by MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide, atetrazole) assay on lung cancer A549 cell lines. In vitro cytotoxicity assay showed that the mPEG-PCL copolymer did not affect the growth of A549 cells. The cytotoxic activity of the micelles against A549 cells was greater than free doxorubicin and free curcumin. é 2017 Zanjan University of Medical Sciences.
dc.language.isoEnglish
dc.relation.ispartofDrug Development and Industrial Pharmacy
dc.subjectcurcumin
dc.subjectdoxorubicin
dc.subjectmacrogol
dc.subjectnanoparticle
dc.subjectpolycaprolactone
dc.subjectantineoplastic agent
dc.subjectcurcumin
dc.subjectdoxorubicin
dc.subjectmacrogol derivative
dc.subjectmethoxy poly(ethylene glycol-co-epsilon-caprolactone)
dc.subjectmicelle
dc.subjectnanoparticle
dc.subjectpolyester
dc.subjectA-549 cell line
dc.subjectArticle
dc.subjectatomic force microscopy
dc.subjectcontrolled study
dc.subjectcytotoxicity assay
dc.subjectdifferential scanning calorimetry
dc.subjectdrug conjugation
dc.subjectdrug cytotoxicity
dc.subjectdrug delivery system
dc.subjectgel permeation chromatography
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthydrophilicity
dc.subjecthydrophobicity
dc.subjectin vitro study
dc.subjectinfrared spectroscopy
dc.subjectmicelle
dc.subjectMTT assay
dc.subjectnanoencapsulation
dc.subjectparticle size
dc.subjectpH
dc.subjectphoton correlation spectroscopy
dc.subjectproton nuclear magnetic resonance
dc.subjectsustained drug release
dc.subjectcell survival
dc.subjectchemical phenomena
dc.subjectchemistry
dc.subjectdrug delivery system
dc.subjectdrug effects
dc.subjectmicelle
dc.subjectprocedures
dc.subjectAntineoplastic Agents
dc.subjectCell Survival
dc.subjectCurcumin
dc.subjectDoxorubicin
dc.subjectDrug Delivery Systems
dc.subjectHumans
dc.subjectHydrophobic and Hydrophilic Interactions
dc.subjectMicelles
dc.subjectNanoparticles
dc.subjectPolyesters
dc.subjectPolyethylene Glycols
dc.titleCo-delivery of hydrophilic and hydrophobic drugs by micelles: a new approach using drug conjugated PEG-PCLNanoparticles
dc.typeArticle
dc.citation.volume43
dc.citation.issue11
dc.citation.spage1908
dc.citation.epage1918
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1080/03639045.2017.1355922


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