Clinical manifestations of patients with novel H1N1 infection hospitalized in Infectious Disease ward, Sina Hospital, Tabriz, Iran

Abstract

Background: Novel H1N1 influenza virus is a unique type of an influenza virus which is built due to abrupt structural alterations. This virus created a pandemic disease. The manifestations and severity may be affected by environmental, cultural and economical condition. Patients and Methods: From October 2009 until December 2009, we had recruited 40 patients with H1N1 infection documented with RT-PCR. Their demographic features and presenting signs and symptoms as well as their associated laboratory data were recorded. Results: During the study period, 40 patients were studied with a mean age of 36.8آ±13.0 years of whom 21 were admitted to ICU. Totally, 37.5% of patients had risk factors. Pneumonia was the most frequent lung involvement. The most prominent radiographic findings were bilateral ground glass opacity and ARDS (25%). Cough and fever was the most prevalent presenting clinical symptoms. Unfortunately, 8 patients died. Independent risk factor of death was ICU admission and mechanical ventilation. Conclusion: Our findings were more or less the same as other centers, however, most of the studied subjects did not have an underlying risk factor. Except for pneumonia and ARDS, bilateral pulmonary thromboembolism were detected in patients all of whom discharged after complete recovery. é 2010 IDTMRC, Infectious Diseases and Tropical Medicine Research Center.