Catalytic activity of (Fe2O3)-MCM-41-nPrNH 2 magnetically recoverable nanocatalyst for the synthesis of phenylpyrido[4,3-d]pyrimidins

Abstract

A new series of phenylpyrido[4,3-d]pyrimidin-2-amin derivatives have been synthesised from the reaction of (E)-3,5-bis(benzylidene)-4-piperidones and guanidine carbonate in the presence of (Fe2O3)-MCM-41- nPrNH2 as a magnetically recoverable nanocatalyst under solvent free conditions. This catalyst was highly recyclable (up to 5 times) and was easily recovered from the reaction mixture using an external magnet without loss of activity. The prepared magnetic catalyst is characterized by Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), and nitrogen physisorption measurements. Also all the structures of title compounds 3a-h were elucidated by comprehensive 1H NMR,13C NMR, IR and Mass spectra. Copyright é 2013 American Scientific Publishers All rights reserved.