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dc.contributor.authorGhorbanzadeh, V
dc.contributor.authorMohammadi, M
dc.contributor.authorDariushnejad, H
dc.contributor.authorAbhari, A
dc.contributor.authorChodari, L
dc.contributor.authorMohaddes, G
dc.date.accessioned2018-08-26T08:38:09Z
dc.date.available2018-08-26T08:38:09Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52900
dc.description.abstractBackground: Crocin is reported to have a wide range of biological activities such as cardiovascular protection. Recent epidemiologic studies have shown that exercise reduces cardiovascular morbidity and mortality in the general population. Objective: The aim of this study was to evaluate the effect of crocin and voluntary exercise on miR-126 and miR-210 expression levels and angiogenesis in the heart tissue. Methods: Animals were divided into 4 groups: control, exercise, crocin, and exercise-crocin. Animals received oral administration of crocin (50 mg/kg) or performed voluntary exercise alone or together for 8 weeks. Akt, ERK1/2 protein levels, miR-126 and miR-210 expression were measured in the heart tissue. Immunohistochemical method was used to detect CD31 in the heart tissue. Results: Akt and ERK1/2 levels of the heart tissue were higher in crocin treated group and voluntary exercise trained group after 8 weeks. Combination of crocin and exercise also significantly enhanced Akt and ERK1/2 levels in the heart tissue. MiR-126, miR-210 expression and CD31 in the heart increased in both crocin and voluntary exercise groups compared with control group. In addition, combination of exercise and crocin amplified their effect on miR-126 and miR-210 expression, and angiogenesis. Conclusion: Crocin and voluntary exercise improve heart angiogenesis possibly through enhancement of miR-126 and miR-210 expression. Voluntary exercise and diet supplementation with crocin could have beneficial effects in prevention of cardiovascular disease. é 2017, Arquivos Brasileiros de Cardiologia. All rights reserved.
dc.language.isoEnglish; Portuguese
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.subjectCD31 antigen
dc.subjectcrocin
dc.subjectmicroRNA 126
dc.subjectmicroRNA 210
dc.subjectmitogen activated protein kinase 1
dc.subjectmitogen activated protein kinase 3
dc.subjectprotein kinase B
dc.subjectcarotenoid
dc.subjectcrocin
dc.subjectmicroRNA
dc.subjectMIRN126 microRNA, human
dc.subjectMIRN210 microRNA, human
dc.subjectprotein kinase B
dc.subjectangiogenesis
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcapillary density
dc.subjectcardiac muscle cell
dc.subjectcontrolled study
dc.subjectdiet supplementation
dc.subjectDNA synthesis
dc.subjectenzyme linked immunosorbent assay
dc.subjectexercise
dc.subjectheart muscle capillary
dc.subjectheart protection
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectnonhuman
dc.subjectphysical activity
dc.subjectprotein expression
dc.subjectrat
dc.subjectreal time polymerase chain reaction
dc.subjectRNA extraction
dc.subjectrunning
dc.subjectsingle drug dose
dc.subjectupregulation
dc.subjectangiogenesis
dc.subjectanimal
dc.subjectanimal experiment
dc.subjectcardiac muscle
dc.subjectexperimental diabetes mellitus
dc.subjectMAPK signaling
dc.subjectmetabolism
dc.subjectphysiology
dc.subjecttime factor
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectCarotenoids
dc.subjectDiabetes Mellitus, Experimental
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMAP Kinase Signaling System
dc.subjectMicroRNAs
dc.subjectMyocardium
dc.subjectNeovascularization, Physiologic
dc.subjectPhysical Conditioning, Animal
dc.subjectProto-Oncogene Proteins c-akt
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTime Factors
dc.titleCardioprotective effect of crocin combined with voluntary exercise in rat: Role of mir-126 and mir-210 in heart angiogenesis [Efeito cardioprotetor de crocina combinado com exerc?cio volunt?rio em ratos: Papel do mir-126 e mir-210 na angiogأھnese card?aca]
dc.typeArticle
dc.citation.volume109
dc.citation.issue1
dc.citation.spage54
dc.citation.epage62
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.5935/abc.20170087


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