Beta-amyloid exhibits antagonistic effects on alpha 7 nicotinic acetylcholine receptors in orchestrated manner

Abstract

Although beta-amyloid (A?) has been regarded as the principal toxic factor in the pathogenesis of Alzheimer's disease (AD), it plays important physiological roles in phenomena such as neuron survival, synaptic plasticity, and memory formation. There are numerous plausible reasons to assume that all of the mentioned pathological and physiological functions of A? may be partially mediated via alpha 7 nicotinic acetylcholine receptor (nAChR). Agonistic and antagonistic aspects of A? on nAChRs may explain this paradox in peptide-receptor function. It seems that A? shows antagonistic effects on ?7 nAChR in a dose-dependent manner, and its pathologic function may partially correlate with antagonization of the receptor. If this hypothesis is supported, the related mechanisms of neurotoxicity, neuroprotection, memory formation, and AD pathogenesis might be identified. In addition, such knowledge helps make a more valid interpretation of neuron signaling and a better design of AD animal models. In addition, it may provide new insights into AD therapy development via reducing the amount of A? and inhibiting peptide aggregation. é 2014 Tehran University of Medical Sciences.