Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer's disease
dc.contributor.author | Sadigh-Eteghad, S | |
dc.contributor.author | Majdi, A | |
dc.contributor.author | Mahmoudi, J | |
dc.contributor.author | Golzari, SEJ | |
dc.contributor.author | Talebi, M | |
dc.date.accessioned | 2018-08-26T08:36:37Z | |
dc.date.available | 2018-08-26T08:36:37Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52762 | |
dc.description.abstract | It is increasingly recognized that astrocytes and microglia-associated dysfunction contribute to AD pathology. In addition, glial nicotinic acetylcholine receptors (nAChRs) play a role in AD-related phenomena, such as neuron survival, synaptic plasticity, and memory. From mechanistic point of view, the glial regulation of pro-inflammatory cytokines, as common contributors in AD, is modulated by nAChRs. Astrocytic and microglial nAChRs contribute to A? metabolism, including A? phagocytosis and degradation as well as A?-related oxidative stress and neurotoxicity. These receptors are also involved in neurotransmission and gliotransmission through indirect interaction with N-Methyl-d-aspartate (NMDA) and a-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) receptors as well as gamma-aminobutyric acid (GABA) and intracellular calcium regulation. In addition, glial nAChRs participate in trophic factors-induced neuroprotection. This review gathers the most recent advances along with the previous data on astrocytic and microglial nAChRs role in AD pathogenesis. أ¯?آ½ 2016, Springer-Verlag Wien. | |
dc.language.iso | English | |
dc.relation.ispartof | Journal of Neural Transmission | |
dc.subject | 4 aminobutyric acid | |
dc.subject | AMPA receptor | |
dc.subject | amyloid beta protein | |
dc.subject | n methyl dextro aspartic acid | |
dc.subject | nicotinic receptor | |
dc.subject | nicotinic receptor | |
dc.subject | Alzheimer disease | |
dc.subject | astrocyte | |
dc.subject | calcium cell level | |
dc.subject | human | |
dc.subject | microglia | |
dc.subject | nervous system inflammation | |
dc.subject | neuroprotection | |
dc.subject | neurotoxicity | |
dc.subject | neurotransmission | |
dc.subject | nonhuman | |
dc.subject | oxidative stress | |
dc.subject | pathogenesis | |
dc.subject | priority journal | |
dc.subject | protein function | |
dc.subject | protein metabolism | |
dc.subject | Review | |
dc.subject | Alzheimer disease | |
dc.subject | animal | |
dc.subject | metabolism | |
dc.subject | pathology | |
dc.subject | physiology | |
dc.subject | Alzheimer Disease | |
dc.subject | Animals | |
dc.subject | Astrocytes | |
dc.subject | Humans | |
dc.subject | Microglia | |
dc.subject | Receptors, Nicotinic | |
dc.title | Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer's disease | |
dc.type | Article | |
dc.citation.volume | 123 | |
dc.citation.issue | 12 | |
dc.citation.spage | 1359 | |
dc.citation.epage | 1367 | |
dc.citation.index | Scopus | |
dc.identifier.DOI | https://doi.org/10.1007/s00702-016-1580-z |
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