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Association of UCP2 -866G>A polymorphism with nonalcoholic fatty liver disease in patients from North-West of Iran

dc.contributor.authorMohseni, F
dc.contributor.authorFarajnia, S
dc.contributor.authorFarhangi, MA
dc.contributor.authorKhoshbaten, M
dc.contributor.authorJafarabadi, M-A
dc.date.accessioned2018-08-26T08:36:31Z
dc.date.available2018-08-26T08:36:31Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52753
dc.description.abstractObjective: To investigate the association of uncoupling protein-2 (UCP2) -866G>A gene polymorphism (rs659366) with nonalcoholic fatty liver disease (NAFLD). Methods: We performed a case-control study with a cohort of 75 patients with NAFLD (of Iranian ethnicity) and 76 healthy individuals of Iranian ethnicity. The UCP2 -866G>A polymorphism (rs659366) was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Patients with AA and AG genotypes were 71% and 68%, respectively, more likely to have NAFLD, compared with individuals with the GG genotype (reference group). In subjects with a GG genotype, serum triglyceride (TG) concentration was significantly higher in patients with NAFLD (P=.04). Serum alanine aminotransferase (ALT) concentrations in all 3 genotypes and serum aspartate aminotransferase (AST) concentrations in AG and GG genotypes of UCP2 gene polymorphism were significantly higher in patients (P <.05). Conclusion: Our results revealed a modest modifier effect of -866G>A UCP2 polymorphism in patients with NAFLD. آ©American Society for Clinical Pathology, 2016. All rights reserved.
dc.language.isoEnglish
dc.relation.ispartofLab Medicine
dc.subjectalanine aminotransferase
dc.subjectaspartate aminotransferase
dc.subjectgenomic DNA
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlow density lipoprotein
dc.subjecttriacylglycerol
dc.subjectuncoupling protein 2
dc.subjectUCP2 protein, human
dc.subjectuncoupling protein 2
dc.subjectadult
dc.subjectalanine aminotransferase blood level
dc.subjectalcohol consumption
dc.subjectArticle
dc.subjectaspartate aminotransferase blood level
dc.subjectbasal metabolic rate
dc.subjectbody composition
dc.subjectbody mass
dc.subjectcase control study
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectDNA polymorphism
dc.subjectfemale
dc.subjectgenotype
dc.subjecthip circumference
dc.subjecthuman
dc.subjectIran
dc.subjectIranian people
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnonalcoholic fatty liver
dc.subjectpolymerase chain reaction
dc.subjectrestriction fragment length polymorphism
dc.subjecttriacylglycerol blood level
dc.subjectwaist circumference
dc.subjectwaist hip ratio
dc.subjectAsian continental ancestry group
dc.subjectgenetics
dc.subjectmiddle aged
dc.subjectnonalcoholic fatty liver
dc.subjectsingle nucleotide polymorphism
dc.subjectAdult
dc.subjectAsian Continental Ancestry Group
dc.subjectCase-Control Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectIran
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNon-alcoholic Fatty Liver Disease
dc.subjectPolymorphism, Single Nucleotide
dc.subjectUncoupling Protein 2
dc.titleAssociation of UCP2 -866G>A polymorphism with nonalcoholic fatty liver disease in patients from North-West of Iran
dc.typeArticle
dc.citation.volume48
dc.citation.issue1
dc.citation.spage65
dc.citation.epage72
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1093/labmed/lmw052


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