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dc.contributor.authorBonyadi, M
dc.contributor.authorNorouzi, N
dc.contributor.authorBabaei, E
dc.contributor.authorJabbarpoor Bonyadi, MH
dc.contributor.authorJavadzadeh, A
dc.contributor.authorYaseri, M
dc.contributor.authorSoheilian, M
dc.date.accessioned2018-08-26T08:36:29Z
dc.date.available2018-08-26T08:36:29Z
dc.date.issued2018
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52748
dc.description.abstractBackground: Age-related macular degeneration (AMD) is a complex disease, and recent studies have shown role of complement system genes in its development. Complement factor I regulates the complement pathways, and relationship between CFI polymorphisms and AMD is controversial. We evaluated the possible association of complement factor I rs141853578 (G119R) variation with advanced AMD in Iranian patients. Materials and methods: We included 371 case-control samples consisting of 220 advanced AMD patients and 151 genetically unrelated healthy controls. Extracted DNA samples amplified to obtain fragment including the polymorphic complement factor I rs141853578 (G119R) region. Results: The distribution of the genotypes was significantly different in the AMD patients compared to that of controls (p = 0.035). The TT genotype frequencies for CFI were significantly higher in AMD group (7.7 vs. 2%, OR 4.67, CI 1.33-16.45, p = 0.016). This significant difference was maintained after adjustment for the effects of age and gender (OR 5.09, CI 1.42-18.20, p = 0.012). The minor allele frequency (T allele) was also significantly higher in AMD patients compared to that of controls (29.3 vs. 21.5% OR 1.51, CI 1.07-2.13, p = 0.018). Conclusion: Current study showed that CFI rs141853578 (G119R) is a risk factor for developing advanced type AMD. This study also suggests that the frequency of G119R polymorphism in our population is not as rare as reported from other populations. é 2018 Springer Science+Business Media B.V., part of Springer Nature
dc.language.isoEnglish
dc.relation.ispartofInternational Ophthalmology
dc.titleAssociation of polymorphisms of complement factor I rs141853578 (G119R) with age-related macular degeneration in Iranian population
dc.typeReview
dc.citation.spage1
dc.citation.epage6
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1007/s10792-018-0835-0


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