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dc.contributor.authorPourhassan, A
dc.date.accessioned2018-08-26T08:36:01Z
dc.date.available2018-08-26T08:36:01Z
dc.date.issued2014
dc.identifier10.3923/pjbs.2014.872.875
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52702
dc.description.abstractIt has been suggested that host genetic diversity may be associated with Hepatitis C (HC). However, available data are tremendously heterogeneous due to the influence of ethnic and geographical differences. This study aimed to investigate possible association between certain Human Leukocyte Antigen (HLA) class-I alleles withHC in a group of Azeri patients for the first time in the literature. In a case-control study, 50 patients with confirmed HC (cases) and 50 healthy age- and sex-matched counterparts (controls) were evaluated in Tabriz Sina and Imam Reza Hospitals in a 2-year period of time (2011-2013). The investigated HLA alleles in the present study were: A2, A3, B35, B38, BW4, CW4 and CW7. The A2-positive cases were significantly more frequent in the case than in the control group (58 vs. 32%, p = 0.01, Odds Ratio (OR) = 2.9). Similar trend was documented for A3 (62 vs. 26%, p<0.001, OR = 4.6), B35 (24 vs. 2%, p= 0.001, OR = 15.5) andBW4 (78 vs. 46%, p = 0.001, OR = 4.2). In contrast the rate of B38-positive (34 vs. 8%, p = 0.001, OR = 0.2) and CW7-positive (38 vs. 14%, p = 0.01, OR = 0.3) cases was significantly higher in the hepatitis-C-negative subjects. There was no significant difference in terms of the rate of CW4-positivity between the two groups (20% in the cases vs. 34% in the controls, p = 0.12, OR = 0.5). This study showed that there are significant associations between certain HLA-I alleles with hepatitis C in Azeri patients. While some alleles make the host prone to the disease, others may have a protective role in this regard. é 2014 Asian Network for Scientific Information.
dc.language.isoEnglish
dc.relation.ispartofPakistan Journal of Biological Sciences
dc.subjectHLA antigen class 1
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectcase control study
dc.subjectfemale
dc.subjecthepatitis C
dc.subjecthuman
dc.subjectimmunology
dc.subjectIran
dc.subjectmale
dc.subjectmiddle aged
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectCase-Control Studies
dc.subjectFemale
dc.subjectHepatitis C
dc.subjectHistocompatibility Antigens Class I
dc.subjectHumans
dc.subjectIran
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectYoung Adult
dc.titleAssociation between human leukocyte antigen class-I and hepatitis C: The first report in Azeri patients
dc.typeArticle
dc.citation.volume17
dc.citation.issue6
dc.citation.spage872
dc.citation.epage875
dc.citation.indexScopus
dc.identifier.DOI10.3923/pjbs.2014.872.875


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