dc.contributor.author | Argani, H | |
dc.contributor.author | Ghorbanihaghjo, A | |
dc.contributor.author | Rashtchizadeh, N | |
dc.contributor.author | Rahbaninobar, M | |
dc.date.accessioned | 2018-08-26T08:34:56Z | |
dc.date.available | 2018-08-26T08:34:56Z | |
dc.date.issued | 2005 | |
dc.identifier.uri | http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52599 | |
dc.description.abstract | Increased serum lipoprotein(a) is an independent risk factor for atherosclerosis in renal transplant recipients. Higher levels may be due to genetic factors, for example, apolipoprotein A isoforms and/or environmental states such as drugs and diets. We evaluated 75 renal transplant recipients including 30 men and 45 women of overall mean age of 30 آ± 7 years and transplantation duration of 57 آ± 10 months as well as 30 healthy controls for apolipoprotein A isoforms, lipoprotein(a) concentrations, serum triglycerides, serum cholesterol, serum creatinine, and serum homocysteine concentrations. High- and low-molecular-weight apolipoprotein A isoforms (>35 and <35 kringle 4) were observed in 71% and 29% of renal transplant recipients and 83% and 17% of controls. Average lipoprotein(a) concentration ratios between high- and low-molecular-weight apolipoprotein A isoenzymes were significantly greater in renal transplant recipients than in controls. Lipoprotein A and cholesterol concentrations that did not correlate with each other were not higher among the eight renal transplant recipients with creatinine levels greater than 1.8 mg/dL. Absolute levels in renal transplant recipients with failed grafts also were not different regarding the various apolipoprotein A phenotypes. Homocysteine levels were significantly higher with high-molecular-weight apolipoprotein A isoenzymes. A relationship existed between lipoprotein(a) and triglycerides, but not cholesterol: higher triglyceride levels were associated more with high-molecular-weight isoforms of apolipoprotein A (P = .027). Lipoprotein(a) concentrations are higher in low-molecular-weight isoforms of apolipoprotein but triglyceride levels and homocysteine concentrations are higher among the high-molecular-weight isoforms of apolipoprotein A. This finding could be used as a guideline to select the most appropriate drug for different apolipoprotein A isoforms. é 2005 by Elsevier Inc. All rights reserved. | |
dc.language.iso | English | |
dc.relation.ispartof | Transplantation Proceedings | |
dc.subject | apolipoprotein A | |
dc.subject | cholesterol | |
dc.subject | creatinine | |
dc.subject | homocysteine | |
dc.subject | lipoprotein A | |
dc.subject | triacylglycerol | |
dc.subject | apolipoprotein A | |
dc.subject | cholesterol | |
dc.subject | creatinine | |
dc.subject | homocysteine | |
dc.subject | isoprotein | |
dc.subject | lipoprotein A | |
dc.subject | triacylglycerol | |
dc.subject | acute graft rejection | |
dc.subject | adult | |
dc.subject | amino acid blood level | |
dc.subject | article | |
dc.subject | cholesterol blood level | |
dc.subject | clinical article | |
dc.subject | comparative study | |
dc.subject | controlled study | |
dc.subject | creatinine blood level | |
dc.subject | disease duration | |
dc.subject | female | |
dc.subject | genetic polymorphism | |
dc.subject | genotype phenotype correlation | |
dc.subject | human | |
dc.subject | kidney graft | |
dc.subject | lipoprotein blood level | |
dc.subject | male | |
dc.subject | molecular weight | |
dc.subject | prediction | |
dc.subject | priority journal | |
dc.subject | protein variant | |
dc.subject | recipient | |
dc.subject | sample size | |
dc.subject | triacylglycerol blood level | |
dc.subject | blood | |
dc.subject | genetics | |
dc.subject | kidney transplantation | |
dc.subject | physiology | |
dc.subject | reference value | |
dc.subject | Adult | |
dc.subject | Apolipoproteins A | |
dc.subject | Cholesterol | |
dc.subject | Creatinine | |
dc.subject | Female | |
dc.subject | Homocysteine | |
dc.subject | Humans | |
dc.subject | Kidney Transplantation | |
dc.subject | Lipoprotein(a) | |
dc.subject | Male | |
dc.subject | Polymorphism, Genetic | |
dc.subject | Protein Isoforms | |
dc.subject | Reference Values | |
dc.subject | Triglycerides | |
dc.title | Apolipoprotein A polymorphysm predicts lipoprotein A concentration in renal transplant recipients | |
dc.type | Article | |
dc.citation.volume | 37 | |
dc.citation.issue | 7 | |
dc.citation.spage | 2925 | |
dc.citation.epage | 2928 | |
dc.citation.index | Scopus | |
dc.identifier.DOI | https://doi.org/10.1016/j.transproceed.2005.07.045 | |