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dc.contributor.authorArgani, H
dc.contributor.authorGhorbanihaghjo, A
dc.contributor.authorRashtchizadeh, N
dc.contributor.authorRahbaninobar, M
dc.date.accessioned2018-08-26T08:34:56Z
dc.date.available2018-08-26T08:34:56Z
dc.date.issued2005
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52599
dc.description.abstractIncreased serum lipoprotein(a) is an independent risk factor for atherosclerosis in renal transplant recipients. Higher levels may be due to genetic factors, for example, apolipoprotein A isoforms and/or environmental states such as drugs and diets. We evaluated 75 renal transplant recipients including 30 men and 45 women of overall mean age of 30 آ± 7 years and transplantation duration of 57 آ± 10 months as well as 30 healthy controls for apolipoprotein A isoforms, lipoprotein(a) concentrations, serum triglycerides, serum cholesterol, serum creatinine, and serum homocysteine concentrations. High- and low-molecular-weight apolipoprotein A isoforms (>35 and <35 kringle 4) were observed in 71% and 29% of renal transplant recipients and 83% and 17% of controls. Average lipoprotein(a) concentration ratios between high- and low-molecular-weight apolipoprotein A isoenzymes were significantly greater in renal transplant recipients than in controls. Lipoprotein A and cholesterol concentrations that did not correlate with each other were not higher among the eight renal transplant recipients with creatinine levels greater than 1.8 mg/dL. Absolute levels in renal transplant recipients with failed grafts also were not different regarding the various apolipoprotein A phenotypes. Homocysteine levels were significantly higher with high-molecular-weight apolipoprotein A isoenzymes. A relationship existed between lipoprotein(a) and triglycerides, but not cholesterol: higher triglyceride levels were associated more with high-molecular-weight isoforms of apolipoprotein A (P = .027). Lipoprotein(a) concentrations are higher in low-molecular-weight isoforms of apolipoprotein but triglyceride levels and homocysteine concentrations are higher among the high-molecular-weight isoforms of apolipoprotein A. This finding could be used as a guideline to select the most appropriate drug for different apolipoprotein A isoforms. é 2005 by Elsevier Inc. All rights reserved.
dc.language.isoEnglish
dc.relation.ispartofTransplantation Proceedings
dc.subjectapolipoprotein A
dc.subjectcholesterol
dc.subjectcreatinine
dc.subjecthomocysteine
dc.subjectlipoprotein A
dc.subjecttriacylglycerol
dc.subjectapolipoprotein A
dc.subjectcholesterol
dc.subjectcreatinine
dc.subjecthomocysteine
dc.subjectisoprotein
dc.subjectlipoprotein A
dc.subjecttriacylglycerol
dc.subjectacute graft rejection
dc.subjectadult
dc.subjectamino acid blood level
dc.subjectarticle
dc.subjectcholesterol blood level
dc.subjectclinical article
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectcreatinine blood level
dc.subjectdisease duration
dc.subjectfemale
dc.subjectgenetic polymorphism
dc.subjectgenotype phenotype correlation
dc.subjecthuman
dc.subjectkidney graft
dc.subjectlipoprotein blood level
dc.subjectmale
dc.subjectmolecular weight
dc.subjectprediction
dc.subjectpriority journal
dc.subjectprotein variant
dc.subjectrecipient
dc.subjectsample size
dc.subjecttriacylglycerol blood level
dc.subjectblood
dc.subjectgenetics
dc.subjectkidney transplantation
dc.subjectphysiology
dc.subjectreference value
dc.subjectAdult
dc.subjectApolipoproteins A
dc.subjectCholesterol
dc.subjectCreatinine
dc.subjectFemale
dc.subjectHomocysteine
dc.subjectHumans
dc.subjectKidney Transplantation
dc.subjectLipoprotein(a)
dc.subjectMale
dc.subjectPolymorphism, Genetic
dc.subjectProtein Isoforms
dc.subjectReference Values
dc.subjectTriglycerides
dc.titleApolipoprotein A polymorphysm predicts lipoprotein A concentration in renal transplant recipients
dc.typeArticle
dc.citation.volume37
dc.citation.issue7
dc.citation.spage2925
dc.citation.epage2928
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1016/j.transproceed.2005.07.045


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