Anti-inflammatory effects of silymarin against damages caused by U.V. irradiation

Abstract

In this study, the protective traits of Silymarin as an herbal medicine were investigated. To this study, 24 albino guinea pigs that were in same age and sex, selected and divided to 4 groups, randomly. Dorsal region of body was shaved in 2أ—2 cm 2 dimension. First treatment group received 9 mg Silymarin with 20 ?lacetone, topically and control group just received acetone. Second treatment group received 50 mg Silymarin, orally and control group received nothing. All groups were irradiated with UV 180 mj/cm 2 for 35 min/day and total time of irradiation was 10 day. The resultsofClinical and Pathological observations showed that Silymarin, especially in topical administration, have significant protective effects on UV lesions. This study showed that Silymarin anti-inflammatory effects are considerable in skin protection against UV radiation damages, especially when used topically. é IDOSI Publications, 2012.