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dc.contributor.authorAlirezaei, AH
dc.contributor.authorBarough, AS
dc.contributor.authorAzizi, T
dc.contributor.authorBarough, SS
dc.contributor.authorGhorbanihaghjo, A
dc.contributor.authorRashtchizadeh, N
dc.contributor.authorBabaie, H
dc.contributor.authorDelazar, A
dc.date.accessioned2018-08-26T08:34:38Z
dc.date.available2018-08-26T08:34:38Z
dc.date.issued2017
dc.identifier10.15171/jrip.2017.35
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52568
dc.description.abstractIntroduction: Immune responses and inflammation are major risk factors for mortality in patients with end-stage renal disease (ESRD). Increased oxidative stress is a common feature of ESRD, and it has been speculated that it is interrelated to inflammation. In many studies it has been proved that red grape seed extract (RGSE) provides an antioxidant efficacy. Objectives: The aim of this study was to investigate the anti-inflammatory effects of RGSE in hemodialysis patients. Patients and Methods: Thirty hemodialysis individuals were divided into two groups that received either 200 mg/day of the RGSE or placebo for one month. Mean آ± SD of age of patients was 58.5 آ± 10.5 years. Duration of dialysis was 4 آ± 3.4 years and 27 patients were male and 3 patients were female. After a 2-week washout period, the groups were crossed over for another one month. Markers of inflammation, lipid profiles and blood factors were measured at baseline after intervention with RGSE or placebo. Results: Our results showed that RGSE consumption could not make statistically significant changes in markers of inflammation, lipid profiles and blood factors in hemodialysis patients. Conclusion: Although RGSE could not improve markers of inflammation, lipid profiles and blood factors in hemodialysis subjects over a 1 month period. However, this result may be due to short period of treatment or low dose of RGSE. Further studies need to clear these contradictions. é 2017 The Author.
dc.language.isoEnglish
dc.relation.ispartofJournal of Renal Injury Prevention
dc.titleAnti-inflammatory effects of grape seed extract in hemodialysis patients; a pilot study
dc.typeArticle
dc.citation.volume6
dc.citation.issue3
dc.citation.spage184
dc.citation.epage187
dc.citation.indexScopus
dc.identifier.DOI10.15171/jrip.2017.35


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