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Antibody humanization methods for development of therapeutic applications

dc.contributor.authorAhmadzadeh, V
dc.contributor.authorFarajnia, S
dc.contributor.authorFeizi, MAH
dc.contributor.authorNejad, RAK
dc.date.accessioned2018-08-26T08:34:37Z
dc.date.available2018-08-26T08:34:37Z
dc.date.issued2014
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52565
dc.description.abstractRecombinant antibody technologies are rapidly becoming available and showing considerable clinical success. However, the immunogenicity of murine-derived monoclonal antibodies is restrictive in cancer immunotherapy. Humanized antibodies can overcome these problems and are considered to be a promising alternative therapeutic agent. There are several approaches for antibody humanization. In this article we review various methods used in the antibody humanization process. é Copyright 2014, Mary Ann Liebert, Inc. 2014.
dc.language.isoEnglish
dc.relation.ispartofMonoclonal Antibodies in Immunodiagnosis and Immunotherapy
dc.subjecthuman monoclonal antibody
dc.subjectibalizumab
dc.subjectmonoclonal antibody
dc.subjectobinutuzumab
dc.subjectofatumumab
dc.subjectrecombinant antibody
dc.subjectrituximab
dc.subjectantineoplastic agent
dc.subjectcomplementarity determining region
dc.subjectmonoclonal antibody
dc.subjectantibody combining site
dc.subjectantibody dependent cellular cytotoxicity
dc.subjectantibody production
dc.subjectantibody structure
dc.subjectantigenicity
dc.subjectbinding affinity
dc.subjectcancer immunotherapy
dc.subjectcomplementarity determining region
dc.subjectHEK293 cell line
dc.subjecthematologic malignancy
dc.subjecthuman
dc.subjectHuman immunodeficiency virus 1 infection
dc.subjectimmunogenicity
dc.subjectnonhodgkin lymphoma
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrevertant
dc.subjectreview
dc.subjecttumor cell
dc.subjectamino acid substitution
dc.subjectanimal
dc.subjectbiosynthesis
dc.subjectgenetics
dc.subjectprocedures
dc.subjectprotein engineering
dc.subjectAmino Acid Substitution
dc.subjectAnimals
dc.subjectAntibodies, Monoclonal, Humanized
dc.subjectAntineoplastic Agents
dc.subjectComplementarity Determining Regions
dc.subjectHumans
dc.subjectProtein Engineering
dc.titleAntibody humanization methods for development of therapeutic applications
dc.typeArticle
dc.citation.volume33
dc.citation.issue2
dc.citation.spage67
dc.citation.epage73
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1089/mab.2013.0080


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