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dc.contributor.authorBabri, S
dc.contributor.authorMohaddes, G
dc.contributor.authorMosaferi, B
dc.date.accessioned2018-08-26T08:33:51Z
dc.date.available2018-08-26T08:33:51Z
dc.date.issued2018
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52480
dc.description.abstractEarly life experiences could determine brain and behavioral development. Neurotrophic factors are likely to mediate the effects of the experience on brain structures and function. Brain-derived neurotrophic factor (BDNF) plays a central role in psychiatric disorders. To investigate the effects of early rearing condition on the amygdala-and serum-BDNF levels, we reared male Wistar rats from weaning (postnatal days 21) to adulthood (postnatal days 119) in three different rearing conditions: (1) enriched, (2) standard and (3) isolated. We found that long-term post-weaning environmental enrichment leads to lower amygdala-and serum-BDNF levels as well as lower brain weights. Grouped rearing in standard laboratory cages enhanced body weight. Thus, early rearing condition might play a crucial role in adult healthiness by predetermining individual BDNF profiles. é 2017 Cambridge University Press and the International Society for Developmental Origins of Health and Disease.
dc.language.isoEnglish
dc.relation.ispartofJournal of Developmental Origins of Health and Disease
dc.titleAmygdala-and serum-neurotrophic factor levels depend on rearing condition in male rats
dc.typeArticle
dc.citation.volume9
dc.citation.issue4
dc.citation.spage377
dc.citation.epage380
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1017/S2040174418000144


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