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dc.contributor.authorMovahhedin, N
dc.contributor.authorZengin, G
dc.contributor.authorBahadori, MB
dc.contributor.authorSarikurkcu, C
dc.contributor.authorBahadori, S
dc.contributor.authorDinparast, L
dc.date.accessioned2018-08-26T08:33:38Z
dc.date.available2018-08-26T08:33:38Z
dc.date.issued2016
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52455
dc.description.abstractThe genus Ajuga is used traditionally as food and medicine. The aim of this study was to investigate the antidiabetic, anti-Alzheimer's diseases, skin-protective, and antioxidant activities of essential oil and extracts of Ajuga chamaecistus subsp. scoparia (Boiss.) Rech.f., together with the identification of their chemical composition. The 1,1-diphenyl-2-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazloine-6-sulfonic acid) radical cation scavenging activity, metal chelating activity, reducing power, content of total bioactive compounds, general toxicity, and enzyme inhibitory potential of essential oil, ethanol extract, and water decoction of the plant were evaluated. Phenolics profile of the extracts was analyzed using the reverse-phase high-performance liquid chromatography with diode array detector and the chemical composition of the essential oil was determined using the gas chromatography and gas chromatography-mass spectroscopy techniques. The essential oil could significantly inhibit the activity of ?-glucosidase (4.3آ mmol Acarbose equivalents/g), ?-amylase (2.8آ mmol Acarbose equivalents/g), acetylcholinesterase (1.96آ mg gallic acid equivalents/g), butyrylcholinesterase (2.2آ mg gallic acid equivalents/g), and tyrosinase (36آ mg kojic acid equivalents/g) while ethanol and water extracts showed moderate enzyme inhibitory activity. Furthermore, essential oil had the strongest antioxidant capacity in the 1,1-diphenyl-2-picrylhydrazyl scavenging, 2,2-azino-bis (3-ethylbenzothiazloine-6-sulfonic acid) scavenging, cupric reducing antioxidant capacity, ferric reducing antioxidant power, and metal chelating assays. Spathulenol (18.0%), thymol (15.1%), octen-3-ol (14.3%), and linalool oxide (11.2%) were identified as major constituents in the essential oil. Quantitative high-performance liquid chromatography analysis indicated that p-coumaric acid, gallic acid, and ferulic acid are the main phenolic compounds in this plant. The results suggested that Ajuga chamaecistus could be useful for several applications as functional foods, cosmetics, and pharmaceuticals. é 2016 Elsevier B.V.
dc.language.isoEnglish
dc.relation.ispartofIndustrial Crops and Products
dc.subjectAntioxidants
dc.subjectChelation
dc.subjectChemical analysis
dc.subjectChromatography
dc.subjectEnzyme activity
dc.subjectEnzymes
dc.subjectEthanol
dc.subjectExtraction
dc.subjectGas chromatography
dc.subjectHigh performance liquid chromatography
dc.subjectLiquid chromatography
dc.subjectMass spectrometry
dc.subjectNeurodegenerative diseases
dc.subjectOils and fats
dc.subjectPhenols
dc.subjectPlants (botany)
dc.subjectAjuga
dc.subjectAlzheimer's disease
dc.subjectCarvacrol
dc.subjectDiabetes mellitus
dc.subjectThymol
dc.subjectTyrosinase
dc.subjectEssential oils
dc.subjectantioxidant
dc.subjectbiochemical composition
dc.subjectdiabetes
dc.subjectdisease incidence
dc.subjectdrug
dc.subjectenzyme activity
dc.subjectessential oil
dc.subjectherb
dc.subjectphenolic compound
dc.subjectphytochemistry
dc.subjectplant extract
dc.subjectscavenging (chemistry)
dc.subjectskin
dc.subjecttoxicity
dc.subjectAjuga
dc.subjectScoparia
dc.titleAjuga chamaecistus subsp. scoparia (Boiss.) Rech.f.: A new source of phytochemicals for antidiabetic, skin-care, and neuroprotective uses
dc.typeArticle
dc.citation.volume94
dc.citation.spage89
dc.citation.epage96
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1016/j.indcrop.2016.08.028


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