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A Novel Stimuli-Responsive Magnetite Nanocomposite as De Novo Drug Delivery System

dc.contributor.authorMozafari, Z
dc.contributor.authorMassoumi, B
dc.contributor.authorJaymand, M
dc.date.accessioned2018-08-26T08:32:36Z
dc.date.available2018-08-26T08:32:36Z
dc.date.issued2018
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52313
dc.description.abstractA novel stimuli-responsive magnetite nanocomposite as de novo drug delivery system for cancer chemotherapy is developed successfully through the incorporation of magnetite nanoparticles into PEG-b-(PNIPAAm-b-PAA)2 copolymer. The chemical structures of samples were characterized using FTIR and 1H NMR spectroscopies. Furthermore, thermal property, morphology, size, and magnetic properties of the nanocomposite were investigated. The DOX loading and encapsulation efficiencies as well as stimuli-responsive drug release ability of the nanosystem were studied. As results, at pH 5.3 and temperature of 41آ°C the nanocomposite exhibited higher drug release values, which qualified it for cancer chemotherapy according to especial features of cancerous tissue. é 2018 Taylor & Francis
dc.language.isoEnglish
dc.relation.ispartofPolymer - Plastics Technology and Engineering
dc.subjectAtom transfer radical polymerization
dc.subjectChemotherapy
dc.subjectControlled drug delivery
dc.subjectDiseases
dc.subjectEncapsulation
dc.subjectMagnetite
dc.subjectMagnetite nanoparticles
dc.subjectNanocomposites
dc.subjectNanosystems
dc.subjectNuclear magnetic resonance
dc.subjectNuclear magnetic resonance spectroscopy
dc.subjectPolyethylene glycols
dc.subjectPolyethylene oxides
dc.subject1H NMR spectroscopy
dc.subjectCancer Chemotherapy
dc.subjectCancerous tissues
dc.subjectDrug delivery system
dc.subjectDrug release
dc.subjectEncapsulation efficiency
dc.subjectSmart drug deliveries
dc.subjectStimuli-responsive
dc.subjectTargeted drug delivery
dc.titleA Novel Stimuli-Responsive Magnetite Nanocomposite as De Novo Drug Delivery System
dc.typeArticle
dc.citation.spage1
dc.citation.epage14
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1080/03602559.2018.1471718


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