| dc.description.abstract | The consolidation and compaction properties of hydroxypropylmethyl cellulose K4M and ibuprofen, and their binary mixtures were evaluated. Powders were compressed using a high-speed compaction simulator at different compression speeds, i.e. 15, 140 and 300 mm/s. Non-linear relationships between tensile strength and composition were found in all the compression speeds studied. Tablets of the individual materials produced at the highest compression speed studied (300 mm/s) had much lower tensile strengths than those produced at the slowest compression speed (15 mm/s). Interestingly, at a compression force of 10 kN, tablets containing 25 and 50% w/w ibuprofen had slightly greater tensile strengths when compressed at the higher compression speed. However, the compression speed did not affect the strength of tablets containing 5, 10, 25 and 50% ibuprofen. | |
