Relationship between potency and boiling point of general anesthetics: a thermodynamic consideration

Abstract

The most important group of nonspecific drugs is that of the general anesthetics. These nonspecific compounds vary greatly in structure, fi om noble gases such as Ar or Xe to complex steroids. Since the development of clinical anesthesia over a century ago, then has been a vast amount of research and speculation concerning the mechanism of action of general anesthetics. Despite these efforts, the exact mechanism remains unknown. Many theories of narcosis do not explain how unconsciousness is produced at a molecular level, but instead relate some physicochemical property of anesthetic agents to their anesthetic potencies. In this paper, we address some of those physicochemical properties, with more emphasis on correlating the anesthetic potency of volatile anesthetics to their boiling points based on thermodynamic principles. (C) 2000 Elsevier Science B.V. All rights reserved.