نمایش پرونده ساده آیتم

dc.contributor.authorNamazi, H
dc.contributor.authorKanani, A
dc.date.accessioned2018-08-26T08:15:47Z
dc.date.available2018-08-26T08:15:47Z
dc.date.issued2009
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/51054
dc.description.abstractSix new prodrugs including conjugated telechelic polymer of beta-cyclodextrin-poly (ethylene glycol)-beta-cyclodextrin (beta-CD-PEG-beta-CD) and or parent beta-cyclodextrin (beta-CD) were designated as the new drug carrier agents containing beta-lactam antibiotics such as ampicillin (AMP), amoxicillin (AMO) and cephalexin (CEP) prodrugs for potentially local administration pharmaceutical applications. Investigation of the drug release dynamics in buffered media with pH 7.4 showed that the drug released through the prodrug matrix with slightly deviation, follows Fickian diffusion mechanism. Using equation "log (M(t)/M(infinity)) = log k + n log t" it has revealed that the synthesized prodrugs 5a-c, 6a-c have the "n" values 0.333, 0.334, 0.390. 0.540, 0.514 and 0.473, respectively. In fact, the prodrug 6c showed the least deviation from Fickian diffusion mechanism. (C) 2008 Elsevier Ltd. All rights reserved.
dc.language.isoEnglish
dc.relation.ispartofCARBOHYDRATE POLYMERS
dc.subjectCyclodextrin
dc.subjectbeta-Lactam
dc.subjectDrug release
dc.subjectFickian diffusion
dc.subjectProdrug
dc.titleInvestigation diffusion mechanism of beta-lactam conjugated telechelic polymers of PEG and beta-cyclodextrin as the new nanosized drug carrier devices
dc.typeArticle
dc.citation.volume76
dc.citation.issue1
dc.citation.spage46
dc.citation.epage50
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.1016/j.carbpol.2008.09.023


فایلهای درون آیتم

فایلهاسایزفرمتنمایش

هیچ فایل مرتبطی وجود ندارد

این آیتم در مجموعه های زیر مشاهده می شود

نمایش پرونده ساده آیتم