| dc.description.abstract | Background: Serum paraoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme that has been implicated in the pathogenesis of aging. Our aim of the study was to investigate whether there were any associations between serum paraoxonase and arylesterase activities with regular exercise during aging. Methods: Two hundred male rats divided into 8 groups consisting, 3, 6, 9, 12 months treadmill exercise groups and a control group for each treadmill exercise groups (n = 25). Rats in all test groups, were run on a treadmill for 60 min/d at a speed of 22m/min 7 degree slope 6 times a week. Results: Mean levels of arylesterase were (101.35 +/- 19.43, 112.88 +/- 16.77, 105.99 +/- 22.91, and 113.03 +/- 14,98) in 3, 6: 9 and 12 months of exercise groups and these amounts were (87.05 +/- 18.90, 90.40 +/- 17.91, 90.98 +/- 22.54, and 102.00 +/- 18.91) for control groups. Mean levels of paraoxonase were (135.02 +/- 18.87, 142.06 +/- 12.52, 144.34 +/- 18.38, and 132.83 +/- 25.32) in 3, 6, 9, and 12 months of exercise groups and these amounts were (118.93 +/- 23.76, 133.67 +/- 8.83, 120.12 +/- 2068, and 121.22 +/- 9.72) for control groups. Discussion: Serum arylesterase levels were significantly increased in animals of exercise compared with control groups during increasing of age (P = 0.04, 0.00, 0.04, and 0.03). Serum paraoxonase levels were significantly increased in animals of exercise compared with control groups during increasing of age (P = 0.03 0.03, 0.00, and 0.04). To our knowledge this is the first study in which the effect of treadmill exercise is shown on serum paraoxonase and arylesterase activities during aging. Mild-intensity treadmill exercise increases significantly serum Arylesterase and Paraoxonase in test groups compared with control groups. | |
