Solubility prediction of clonazepam in aqueous mixtures of ethanol, polyethylene glycol 200 and propylene glycol at 30 degrees C

Abstract

Solubility of clonazepam in aqueous binary mixtures of ethanol, polyethylene glycol 200 and propylene,glycol was determined at 30 C using the shake flask method. The maximum solubility of clonazepam was observed at volume fraction of 0.90 of ethanol, whereas for aqueous mixtures of polyethylene glycol 200 and propylene,glycol, the maximum values were observed in the neat cosolvents. The generated dam was lined to the Jouyban-Acree model and its constants were computed, then the back-calculated solubilities lucre compared with the corresponding experimental values by calculating the mean percentage deviation (MPD) in which the overall MPD for three cosolvent systems was 7.0 %. The solubility data in cosolvent + water mixtures was predicted using previously trained versions of the Jouyban-Acree model and the prediction MPDs were 13.4, 54.2 and 24.9 %, respectively for ethanol, polyethylene,glycol 200 and pmpylene glycol mixtures and the overall MED was 30.8 %.