STUDY ON HLA-DQB1*03 ALLELE ASSOCIATED WITH WOMEN HUMAN PAPILLOMA VIRUS (HPV) LESIONS

Abstract

Objectives: The specific HLA alleles associated with HPV differ among various study groups. It has been suggested that women carrying HLA-DQw3 antigen encoded by DQB 1*03, are predisposed to develop cervical cancer. The aim of this study was to determine HLA-DQB1*03 alleles in HPV lesions. Methodology: In a cross-sectional and analytical study, Hundred women enrolled into the study. Twenty of them had abnormal Pap smear, Fifty patients had condyloma lesions and 30 patients with malignant lesions. HLA-DQB*03 and HPV infection was evaluated by PCR. Results: PCR of HPV was positive in 50 women with condyloma lesions and 8 women with malignant lesion (p< 0.001). HLA-DQB*03 was positive in 9 women with abnormal Pap smear, 18 women with condyloma lesions and 7 women with malignant lesion(P= 0.261). Positive PCR of HPV was significantly higher in women with condyloma lesions than other women (p< 0.001). Mean age of patients with positive PCR of HPV was significantly lower than patients with negative PCR of HPV (P= 0.001). Mean age of patients with positive HLA-DQB*03 was 42.08 + 11.48 year and mean age of patients with negative HLA-DQB*03 Was 43.83 + 11.21 year (P= 0.462). HLA-DQB*03 was positive in 34% of patients. Conclusion: In this study, we do not see any significant correlation between HPV infection and HLA-DQB*03 in the studied women.