Solubility of Acetaminophen and Ibuprofen in the Mixtures of Polyethylene Glycol 200 or 400 with Ethanol and Water and the Density of Solute-Free Mixed Solvents at 298.2 K

Abstract

Experimental solubilities of acetaminophen and ibuprofen in binary and ternary mixtures of polyethylene glycols (PEGs) 200 and 400 with ethanol and water, along with the densities of the saturated and solute-free solvent mixtures at T = 298.2 K, are reported. The solubility data of each drug in the ternary and sub-binary solvent mixtures were correlated with the Jouyban-Acree model. The mean relative deviations of the derived correlations were 6.4 % and 14.2 % for acetaminophen and ibuprofen, respectively, and the overall value was 9.4 %. Densities of solute-free solvent mixtures are used to train the Jouyban-Acree model, and then the densities of saturated solutions are predicted using the trained versions in which the overall mean relative deviation was 1.7 %.