Solubility of 2-Butyl-3-benzofuranyl 4-(2-(Diethylamino)ethoxy)-3,5-diiodophenyl Ketone Hydrochloride (Amiodarone HCl) in Ethanol plus Water and N-Methyl-2-pyrrolidone plus Water Mixtures at Various Temperatures

Abstract

The solubilities of amiodarone HCl (AMDH) in binary mixtures of ethanol + water and N-methyl pyrrolidone (NMP) + water at (293.2, 298.2, 303.2, 308.2, and 313.2) K are reported. In the ethanol + water system the maximum solubility of AMDH was observed at 313.2 K and an ethanol mass fraction of 0.76. The combination of the Jouyban-Acree model and van't Hoff equation was used to predict the solubility of AMDH in the mixed solvents at different temperatures. A mean relative deviation of 12.2 % was obtained for the correlated data. The standard enthalpy, entropy,and Gibbs energy changes of solutions for AMDH in ethanol + water and NMP + water mixtures were calculated from the measured solubility data using the modified version of the van't Hoff equation.