| dc.contributor.author | Ghasemi, S | |
| dc.contributor.author | Sharifi, S | |
| dc.contributor.author | Davaran, S | |
| dc.contributor.author | Danafar, H | |
| dc.contributor.author | Asgari, D | |
| dc.contributor.author | Mojarrad, JS | |
| dc.date.accessioned | 2018-08-26T08:04:00Z | |
| dc.date.available | 2018-08-26T08:04:00Z | |
| dc.date.issued | 2013 | |
| dc.identifier.uri | http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/49440 | |
| dc.description.abstract | A series of substituted 3-chlorophenylpiperazinone derivatives were synthesised using L-778123 (an imidazole-containing FTase inhibitor) as a model by bioisosteric replacement of the imidazole ring. The final compounds were evaluated against two human cancer cell lines including A549 (lung cancer) and HT-29 (colon cancer) by MTT assay. The results showed that substitution of imidazole ring with 1-amidinourea, semicarbazide, and thiobiuret led to improvement of cytotoxic activity against both cell lines. | |
| dc.language.iso | English | |
| dc.relation.ispartof | AUSTRALIAN JOURNAL OF CHEMISTRY | |
| dc.title | Synthesis and Cytotoxicity Evaluation of Some Novel 1-(3-Chlorophenyl)piperazin-2-one Derivatives Bearing Imidazole Bioisosteres | |
| dc.type | Article | |
| dc.citation.volume | 66 | |
| dc.citation.issue | 6 | |
| dc.citation.spage | 655 | |
| dc.citation.epage | 660 | |
| dc.citation.index | Web of science | |
| dc.identifier.DOI | https://doi.org/10.1071/CH13031 | |
