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dc.contributor.authorEteraf-Oskouei, T
dc.contributor.authorShaseb, E
dc.contributor.authorGhaffary, S
dc.contributor.authorNajafi, M
dc.date.accessioned2018-08-26T07:58:00Z
dc.date.available2018-08-26T07:58:00Z
dc.date.issued2013
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/49157
dc.description.abstractPotential protective effects of prolonged preconditioning with natural honey against myocardial infarction were investigated. Male Wistar rats were pre-treated with honey (1%, 2% and 4%) for 45 days then their hearts were isolated and mounted on a Langendorff apparatus and perfused with a modified Krebs-Henseleit solution during 30 mm regional ischemia fallowed by 120 min reperfusion. Two important indexes of ischemia-induced damage (infarction size and arrhythmias) were determined by computerized planimetry and ECG analysis, respectively. Honey (1% and 2%) reduced infarct size from 23 +/- 3.1% (control) to 9.7 +/- 2.4 and 9.5 +/- 2.3%, respectively (P<0.001). At the ischemia, honey (1%) significantly reduced (P<0.05) the number and duration of ventricular tachycardia (VT). Honey (1% and 2%) also significantly decreased number of ventricular ectopic beats (VEBs). In addition, incidence and duration of reversible ventricular fibrillation (Rev VF) were lowered by honey 2% (P<0.05). During reperfusion, honey produced significant reduction in the incidences of VT, total and Rev VF, duration and number of VT. The results showed cardioprotective effects of prolonged pre-treatment of rats with honey following myocardial infarction. Maybe, the existence of antioxidants and energy sources (glucose and fructose) in honey composition and improvement of hemodynamic functions may involve in those protective effects.
dc.language.isoEnglish
dc.relation.ispartofPAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.subjectHoney
dc.subjectmyocardial infarction
dc.subjectischemia
dc.subjectreperfusion
dc.subjectrat
dc.titleProlonged preconditioning with natural honey against myocardial infarction injuries
dc.typeArticle
dc.citation.volume26
dc.citation.issue4
dc.citation.spage681
dc.citation.epage686
dc.citation.indexWeb of science
dc.citation.URLhttp://localhost/pjps/wp-content/uploads/pdfs/CD-PJPS-26-4-13/Paper-4.pdf
dc.citation.URLhttps://applications.emro.who.int/imemrf/Pak_J_Pharm_Sci/Pak_J_Pharm_Sci_2013_26_4_681_686.pdf


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