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Multiple sclerosis and mitochondrial gene variations: A review

dc.contributor.authorAndalib, S
dc.contributor.authorTalebi, M
dc.contributor.authorSakhinia, E
dc.contributor.authorFarhoudi, M
dc.contributor.authorSadeghi-Bazargani, H
dc.contributor.authorMotavallian, A
dc.contributor.authorPilehvar-Soltanahmadi, Y
dc.date.accessioned2018-08-26T07:57:53Z
dc.date.available2018-08-26T07:57:53Z
dc.date.issued2013
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/49139
dc.description.abstractMultiple sclerosis (MS) is a debilitating disease of the central nervous system. Its etiology is still an unanswered enigma; its symptoms are varied and unpredictable; and there is no cure for it Genetics has been introduced as a contributing factor to MS. Not only may MS stem from nuclear gene variations/mutations, but also it may arise from mitochondrial gene variations/mutations. The association of mitochondrial DNA variations/mutations with the pathogenesis of MS has, so far, been analyzed by several studies. This paper reviews the literature with regard to MS and corresponding mitochondrial DNA variations. (C) 2013 Elsevier B.V. All rights reserved.
dc.language.isoEnglish
dc.relation.ispartofJOURNAL OF THE NEUROLOGICAL SCIENCES
dc.subjectMultiple sclerosis
dc.subjectMitochondrial dysfunction
dc.subjectMitochondrial gene variation
dc.subjectMitochondrial DNA nucleotide position
dc.subjectGenetic susceptibility
dc.subjectCentral nervous system
dc.titleMultiple sclerosis and mitochondrial gene variations: A review
dc.typeReview
dc.citation.volume330
dc.citation.issue1-2
dc.citation.spage10
dc.citation.epage15
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.1016/j.jns.2013.04.018


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