Show simple item record

dc.contributor.authorSoltanpour, S
dc.contributor.authorJafari, B
dc.contributor.authorBarzegar-Jalali, M
dc.contributor.authorJouyban, A
dc.date.accessioned2018-08-26T07:56:41Z
dc.date.available2018-08-26T07:56:41Z
dc.date.issued2014
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/48884
dc.description.abstractExperimental solubilities of glibenclamide polyethylene glycol400 (PEG 400)-water, propylene glycol (PG)-water and N-methyl-pyrrolidone (NMP)-water mixtures at 298.2 K, and the experimental solubility in the mono-solvents at 298.2. 303.2. 308.2 and 313.2 K are reported. The Jouyban-Acree model was used to fit the solubility data of each drug in the binary solvent mixtures in which the mean relative deviations (MRD)for aqueous mixtures of PEG 400, PG and NMP were 75, 17.1 and 29.2 %, respectively, and the overall value was 17.9%. The van't Hoff equation was used loft the solubility data in mono-solvents at four different temperatures in which the overall MRD value was 72 %. A predictive method for density of saturated solutions of glibenclamide in binary solvents using the trained versions of the Jouyban-Acree model and the experimental densities of the saturated solutions in the mono-solvents was also presented.
dc.language.isoEnglish
dc.relation.ispartofJOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
dc.subjectGlibenclamide
dc.subjectSolubility
dc.subjectAqueous binary mixtures
dc.subjectJouyban-Acree model
dc.titleSolubility of glibenclamide in the aqueous mixtures of polyethylene glycol 400, propylene glycol and N-methyl-pyrrolidone at 298.2 K
dc.typeArticle
dc.citation.volume24
dc.citation.issue1
dc.citation.spage111
dc.citation.epage115
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.1016/S1773-2247(14)50016-0


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record