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dc.contributor.authorOrang, AV
dc.contributor.authorBarzegari, A
dc.date.accessioned2018-08-26T07:56:37Z
dc.date.available2018-08-26T07:56:37Z
dc.date.issued2014
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/48863
dc.description.abstractColorectal cancer (CRC) is one of the major healthcare problems worldwide and its processes of genesis include a sequence of molecular pathways from adenoma to carcinoma. The discovery of microRNAs, a subset of regulatory non-coding RNAs, has added new insights into CRC diagnosis and management. Together with several causes of colorectal neoplasia, aberrant expression of oncomiRs (oncogenic and tumor suppressor miRNAs) in cancer cells was found to be indirectly result in up-or down-regulation of targeted mRNAs specific to tumor promoter or inhibitor genes. The study of miRNAs as CRC biomarkers utilizes expression profiling methods from traditional tissue samples along with newly introduced non-invasive samples of faeces and body fluids. In addition, miRNAs could be employed to predict chemo-and radio-therapy responses and be manipulated in order to alleviate CRC characteristics. The scope of this article is to provide a comprehensive review of scientific literature describing aberrantly expressed miRNAs, and consequently dysregulation of targeted mRNAs along with the potential role of miRNAs in CRC diagnosis and prognosis, as well as to summarize the recent findings on miRNA-based manipulation methods with the aim of advancing in anti-CRC therapies.
dc.language.isoEnglish
dc.relation.ispartofASIAN PACIFIC JOURNAL OF CANCER PREVENTION
dc.subjectColorectal cancer
dc.subjectmicroRNA
dc.subjectbiomarker
dc.subjectcancer therapy
dc.titleMicroRNAs in Colorectal Cancer: from Diagnosis to Targeted Therapy
dc.typeReview
dc.citation.volume15
dc.citation.issue17
dc.citation.spage6989
dc.citation.epage6999
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.7314/APJCP.2014.15.17.6989


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