Solubility of fluphenazine decanoate in aqueous mixtures of polyethylene glycols 400 and 600 at various temperatures

Abstract

The solubility of fluphenazine decanoate (FD) in aqueous binary mixtures of polyethylene glycols 400 (PEG 400) and 600 (PEG 600) at 298.0-318.0 K and atmospheric pressure along with some thermodynamic properties are reported. The previously trained version of the Jouyban-Acree model for PEG 400 + water, a recently proposed general cosolvency model employing partial solubility parameters, and a combination of the model with van't Hoff equation were used to predict the solubility of FD in PEG 400 + water and PEG 600 + water at different temperatures. The results show that the Jouyban-Acree model can be used for solubility prediction of FD in aqueous mixtures of PEG 400 and PEG 600 at different temperatures. Densities of solute free aqueous mixtures of PEG 400 and PEG 600 along with their FD-saturated solutions are also reported. (C) 2014 Elsevier B.V. All rights reserved.