Solubility of naproxen in 2-propanol + water mixtures at various temperatures

Abstract

The experimental solubility of naproxen in 2-propanol + water mixtures at different temperatures (298.2,303.2, 3082 and 313.2 K) was reported. The solubility was correlated and/or predicted using three numerical methods; i.e., the combined van't Hoff equation and Jouyban-Acree model (method I), the extended version of the Jouyban-Acree model with Abraham parameters (method II), and the minimum number of data points (N = 10) were used to train the combined model. The accuracies of the calculated solubilities were evaluated by computing the mean percentage deviation (MPD). The obtained MPDs for investigated numerical analyses varied between 13 and 30%. (C) 2015 Elsevier B.V. All rights reserved.