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dc.contributor.authorFarimani, MM
dc.contributor.authorBahadori, MB
dc.contributor.authorKoulaei, SA
dc.contributor.authorSalehi, P
dc.contributor.authorEbrahimi, SN
dc.contributor.authorKhavasi, HR
dc.contributor.authorHamburger, M
dc.date.accessioned2018-08-26T07:41:54Z
dc.date.available2018-08-26T07:41:54Z
dc.date.issued2015
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/47684
dc.description.abstractTwo new triterpenoids, urmiensolide B (1) and urmiensic acid (2), with rare carbon skeletons together with three known compounds were isolated from the aerial parts of Salvia urmiensis Bunge, an endemic species of Iran. The structures were established by a combination of 1D and 2D NMR, and HRESIMS, and in the case of 2 and 3, their structures were confirmed by single-crystal X-ray analysis. The absolute configuration of 2 was established by electronic circular dichroism (ECD) spectra. The new compounds were evaluated for their anti-proliferative activities against A549 and MCF-7 human cancer cell lines. Compounds 1 and 2 showed IC50 values of 2.8 and 1.6 mu M against MCF-7 cells, respectively. (C) 2015 Elsevier B.V. All rights reserved.
dc.language.isoEnglish
dc.relation.ispartofFITOTERAPIA
dc.subjectSalvia urmiensis
dc.subjectTriterpenoids
dc.subjectAbsolute configuration
dc.subjectAnti-proliferative activity
dc.titleNew ursane triterpenoids from Salvia urmiensis Bunge: Absolute configuration and anti-proliferative activity
dc.typeArticle
dc.citation.volume106
dc.citation.spage1
dc.citation.epage6
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.1016/j.fitote.2015.07.017


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