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dc.contributor.authorNami, Y
dc.contributor.authorHaghshenas, B
dc.contributor.authorHaghshenas, M
dc.contributor.authorAbdullah, N
dc.contributor.authorKhosroushahi, AY
dc.date.accessioned2018-08-26T07:41:35Z
dc.date.available2018-08-26T07:41:35Z
dc.date.issued2015
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/47585
dc.description.abstractEnterococcus lactis IW5 was obtained from human gut and the potential probiotic characteristics of this organism were then evaluated. Results showed that this strain was highly resistant to low pH and high bile salt and adhered strongly to Caco-2 human epithelial colorectal cell lines. The supernatant of E. lactis IW5 strongly inhibited the growth of several pathogenic bacteria and decreased the viability of different cancer cells, such as HeLa, MCF-7, AGS, HI 29, and Caco-2. Conversely, E. lactis IW5 did not inhibit the viability of normal FHs-74 cells. This strain did not generate toxic enzymes, including 13-glucosidase, j3-glucuronidase, and N-acetyl-beta-glucosaminidase and was highly susceptible to ampicillin, gentamycin, penicillin, vancomycin, clindamycin, sulfamethoxazol, and chloramphenicol but resistant to erythromycin and tetracyclin. This study provided evidence for the effect of E lactis IW5 on cancer cells. Therefore, E. lactis IW5, as a bioactive therapeutics, should be subjected to other relevant tests to verify the therapeutic suitability of this strain for clinical applications.
dc.language.isoEnglish
dc.relation.ispartofFRONTIERS IN MICROBIOLOGY
dc.subjectanticancer
dc.subjectenzyme activity
dc.subjectantibiotic susceptibility
dc.subjectapoptosis
dc.subjectcytotoxicity
dc.titleThe Prophylactic Effect of Probiotic Enterococcus lactis IW5 against Different Human Cancer Cells
dc.typeArticle
dc.citation.volume6
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.3389/fmicb.2015.01317


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