Solubility of naproxen in some aqueous mixtures of N-methyl-2-pyrrolidone at various temperatures

Abstract

The experimental solubility of naproxen in some N-methyl-2-pyrrolidone + water mixtures at different temperatures (293.2, 298.2, 303.2, 308.2 and 313.2 K) was reported. The solubility was mathematically represented using two numerical methods; i.e., the combined van't Hoff equation and Jouyban-Acree model and its derived version employing all solubility data points (method I) and the minimum number of data points (N = 10, method II) were used to train the combined models. The accuracies of the correlated/predicted solubilities were evaluated by computing mean relative percentage deviation (MRPD). The obtained MRPDs for investigated numerical analyses were less than 6 %. A number of thermodynamic parameters were also computed using the generated solubility data to provide more details on the mechanism of dissolution. (c) 2016 Elsevier B.V. All rights reserved.