The effects of Permethrin and antioxidant properties of Allium cepa (onion) on testicles parameters of male rats

Abstract

The aim of this study was to evaluate the effects of Permethrin on the testes of adult Wistar rats, and evaluate the efficacy of Onion juice supplementation. The male rats were divided into five groups: I: control; II: DMSO (0/5ml); III: Permethrin (35mg/kg) in 0/5ml DMSO; IV: Permethrin (35mg/kg)+Onion (3ml); V: onion (3ml). After 60 days, male rats in all groups prepared to evaluate genital organs weights, the Leydig cells culturing and measurement of testosterone hormone level. Permethrin have negative impacts on Sperm parameters, the Leydig cells count and reduced testosterone serum level in groups 3 and 4. However, in group 4, ONION with antioxidant properties can modify these effects. Onion showed a significant remedy effect on sperm parameters and also leads to increases in the number of Leydig cells. These findings indicated that Permethrin have the negative effects on the reproductive system and fertility.