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dc.contributor.authorSalatin, S
dc.contributor.authorBarar, J
dc.contributor.authorBarzegar-Jalali, M
dc.contributor.authorAdibkia, K
dc.contributor.authorKiafar, F
dc.contributor.authorJelvehgari, M
dc.date.accessioned2018-08-26T07:22:42Z
dc.date.available2018-08-26T07:22:42Z
dc.date.issued2017
dc.identifier10.4103/1735-5362.199041
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/46312
dc.description.abstractRivastigmine hydrogen tartrate (RHT), one of the potential cholinesterase inhibitors, has received great attention as a new drug candidate for the treatment of Alzheimer's disease. However, the bioavailability of RHT from the conventional pharmaceutical forms is low because of the presence of the blood brain barrier. The main aim of the present study was to prepare positively charged Eudragit RL 100 nanoparticles as a model scaffold for providing a sustained release profile for RHT. The formulations were evaluated in terms of particle size, zeta potential, surface morphology, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Drug entrapment efficiency and in vitro release properties of lyophilized nanoparticles were also examined. The resulting formulations were found to be in the size range of 118 nm to 154 nm and zeta potential was positive (+ 22.5 to 30 mV). Nanoparticles showed the entrapment efficiency from 38.40 +/- 8.94 to 62.00 +/- 2.78%. An increase in the mean particle size and the entrapment efficiency was observed with an increase in the amount of polymer. The FTIR, XRD, and DSC results ruled out any chemical interaction between the drug and Eudragit RL100 polymer. RHT nanoparticles containing low ratio of polymer to drug (4: 1) presented a faster drug release and on the contrary, nanoparticles containing high ratio of polymer to drug (10: 1) were able to give a more sustained release of the drug. The study revealed that RHT nanoparticles were capable of releasing the drug in a prolonged period of time and increasing the drug bioavailability.
dc.language.isoEnglish
dc.relation.ispartofRESEARCH IN PHARMACEUTICAL SCIENCES
dc.subjectRivastigmine hydrogen tartrate
dc.subjectNanoparticles
dc.subjectEudragit RL100
dc.subjectNanoprecipitation
dc.titleDevelopment of a nanoprecipitation method for the entrapment of a very water soluble drug into Eudragit RL nanoparticles
dc.typeArticle
dc.citation.volume12
dc.citation.issue1
dc.citation.spage1
dc.citation.epage14
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.4103/1735-5362.199041


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