Solubilization of bosentan using ethanol as a pharmaceutical cosolvent

Abstract

Solubility of bosentan in ethanol + water mixtures was experimentally determined at five different temperatures (293.2-313.2 K) with respect to the composition of the solvent mixture. Results indicate an ethanol and temperature dependent increase in bosentan solubility. Thermodynamic properties of the solution process were calculated using van't Hoff and Gibbs equations. Generated solubility data were correlated with a number of cosolvency models and the accuracies of the predicted solubilities and model performance were illustrated by mean percentage deviation (MPD). The obtained MPD values for cosolvency models trained using whole data points varied between 5.8 and 462%. (C) 2017 Elsevier B.V. All rights reserved.