Solubilization of lamotrigine using Tween 80 and ethylene glycol or propylene glycol

Abstract

Micellar medium as solubilization technique is an influential approach for solubilization of drugs with high hydrophobicity. In the current work, the effects of Tween 80 as a nonionic surfactant on the solubilities of lamotrigine in binary mixtures of ethylene glycol + water and propylene glycol + water at 298 K are investigated. To measure solubility of lamotrigine a lab-made setup was employed. This setup applies a synthetic-based method to measure the solubility of the candidate drugs using a three-step procedure to check the solution saturation point. Measured solubility data points were fitted to the common cosolvency models and then back-calculated solubilities were used to calculate the mean percentage deviation (MPD) as an accuracy measure of the models. The obtained MPDs for back-calculated and predicted solubilities using Jouyban-Acree model were 4.0 and 6.9%, respectively. (C) 2017 Elsevier B.V. All rights reserved.